As for the rest, your statement that:
is utterly absurd. First of all, Judaism is not monolithic. Emden wasn't wasn't the pope of the Jews, and his opinions were not accepted as the rule of law by all Jews. Secondly, most of the maskilim (enlightened Jews) couldn't have cared less about Emden's ruling, and and the Jews who really acculturated (much less assimilated) were precisely those who cared the least about the halachic ramifications of their actions. If you can show me where anybody based their embrace of the haskalah on having Emden's permission to do so, please present it.The Jewish enlightenment and assimilation of the 19th Century, and the large-scale participation of Western Jews in modern civilisation, was a result of Rabbi Emden's ruling.
EDIT--I read what I could of Biale on googlebooks, but the only thing I could find was a very minor reference to Emden, without any context. In the world of Jewish law, rabbis get asked questions all the times, so was don't know from this who was asking it, or why, or who, if anybody, acted upon it. Certainly, there's nothing there to suggest that Emden's statement was particularly influential or transformative. All it says is that he "cleared the way for a much closer relationship between the Jews and the nations in which they lived." "Cleared the way" is a fairly vague statement. Moreover, the specific reference was not to "christians," but that "the nations of Europe were not the descendants of ancient Rome, the claims of the Holy Roman Empire notwithstanding," so it certainly doesn't support the notion that this is some ancient opinion. For all we know, somebody wrote to him and said "Rabbi, if Rome is Edom, can we associate with the Holy Roman Empire?"
Also, based solely on searching the book with the terms you used, like blood and guilt and inherited and edom and temple and christians I don't turn up anything like what you said. Granted, it's an imperfect method, but until I can get a copy of it, the best I can do.